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An estimated 23 million American adults have chronic kidney disease. Currently the NIH spends $655 million on kidney disease research. With good care, fewer than 10 percent of diabetics develop kidney failure.  Management of complications has markedly improved the quality of life of dialysis patients.  Dialysis dementia due to aluminum toxicity no longer occurs.

Premature death due to cardiovascular disease and all other causes are higher in adults with chronic kidney disease. Individuals with chronic kidney disease are 16 to 40 times more likely to die than to progress to kidney failure. High cardiovascular death rates in dialysis patients are also a serious problem.

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